Key result
Tpm1.6, Tpm1.7, and TPM1 mRNA expression decreased considerably in squamous cell carcinoma of esophagus tissues relative to normal esophageal tissues (p < 0.001).
Observational
Downregulation of Tpm1.6 and Tpm1.7 is associated with squamous cell carcinoma of the esophagus and may serve as a biomarker for poor prognosis.
Tpm1.6/Tpm1.7 expression may aid SCCE prognostication; leaves open biomarker validation in prospective cohorts.
AIM: Squamous cell carcinoma of esophagus (SCCE) is an aggressive disease with a poor prognosis. Tropomyosins attach to actin microfilaments, providing its stability. Nonmuscle cells express Tpm isoforms such as Tpm1.6 and Tpm1.7 which are involved in cytoskeleton functional properties regulation. MATERIALS & METHODS: The expression of Tpm1.6 and Tpm1.7 was analyzed in SCCE tissues and its association with clinicopathological parameters and survival of patients was assessed. RESULTS: Tpm1.6 and Tpm1.7, besides TPM1 mRNA decreased considerably in SCCE tissues relative to normal esophageal tissues (p < 0.001). TPM1 downregulation level was significantly associated with the degree of tumor differentiation (p = 0.017). CONCLUSION: Tpm1.6 and Tpm1.7 suppression play a crucial role in esophagus tumorigenesis and could be associated with SCCE poor prognosis.
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Zare et al. (2018) conducted an observational in Squamous cell carcinoma of esophagus (SCCE). Tpm1.6 and Tpm1.7 expression vs. Normal esophageal tissues was evaluated on Expression of Tpm1.6, Tpm1.7, and TPM1 mRNA (p=<0.001). Tpm1.6, Tpm1.7, and TPM1 mRNA expression decreased considerably in squamous cell carcinoma of esophagus tissues relative to normal esophageal tissues (p < 0.001).
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