Solvent-Free Preparation of Glycosyl Isothiocyanates

All articles of this category By a novel solvent-free procedure, peracetylated glycosyl bromides are reacted with potassium thiocyanate in the melt to give the corresponding glycosyl isothiocyanates. The method is applicable to several glycosyl bromides tested, including classical hexoses and pentoses, deoxy sugars and even disaccharides. No glycosyl thiocyanates are obtained. In general, the glycosyl isothiocyanates are formed stereoselectively having 1,2- trans configuration in yields between 41-74%. carbohydrate synthesis melting procedure glycosyl isothiocyanates disaccharide isothiocyanates glycosyl bromides