New perspectives for an unpopular reaction? An 8π electrocyclization has been used to construct the eight-membered ring of 5,8,5- and 6,4,8,5-polycyclic systems in a one-pot 4-exo-dig cyclocarbopalladation/Stille coupling/electrocyclization sequence (see scheme). The polycycles obtained have the framework of biologically important compounds such as the ophiobolins. R=Et, Me; n=0, 1.
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Salem et al. (2004) studied this question.
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