Simple and Versatile Synthesis of Optically Active 1,2‐Amino Alcohols by Grignard Addition toN,O‐Dibenzylglyceraldimine and ‐lactaldimine

In many cases with high threo selectivity, Grignard additions can be performed on simple, nonactivated, and even enolizable imine derivatives of optically active aldehydes, as the reactions with 1 and 2 show. This should open a new route to aminohydroxy acids that supplements the familiar one starting from α-amino acids/aldehydes.