Generation of Heteroatom-Substituted Carbene Complexes of Iridium by Double C−H Activation of Ether and Amine Substrates

Regioselective, double C−H activation of a variety of ether and amine substrates, as exemplified with an ether in [Eq. (1)], is effected by the IrI compound [Ir(κ3-TpPh)(η4-isoprene)]). The formation of the corresponding Fischer-type carbenes follows the activation reaction. TpPh=hydridotris(3-phenylpyrazol-1-yl)borate.