Key result
Accumulating evidence indicates that activation of the tissue factor pathway plays an important role in intravascular thrombus formation following arterial injury.
Tissue factor inhibition may represent a therapeutic approach to reduce thrombosis following vascular injury.
Tissue factor inhibition merits exploration as antithrombotic strategy after arterial injury; hypothesis-generating and requires prospective trials before clinical adoption.
Vascular injury induces haemostasis with subsequent thrombus formation. Accumu-lating evidence indicates that activation of the tissue factor (TF) pathway may play an important role in the pathophysiology of intravascular thrombus formation follow-ing arterial injury. A variety of cell types like monocytes, smooth muscle cells, foam cells and endothelial cells express TF in athero-sclerotic lesions (1). In the plaque, TF is also present on microparticles within the ne-crotic core that are derived from apoptotic foam cells or macrophages, respectively. Moreover, the number of circulating TF-positive microparticles is increased in pa-
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Ilka Ott (2009) conducted a review in Thrombosis after vascular injury. Tissue factor inhibition was evaluated. Accumulating evidence indicates that activation of the tissue factor pathway plays an important role in intravascular thrombus formation following arterial injury.