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Experimentally induced lesions were investigated in animal models to correlate with sensory disturbances of poliomyelitis, with no quantitative results reported in the truncated abstract.
This preclinical study aims to correlate experimentally induced lesions with the sensory disturbances and pain experienced in poliomyelitis.
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Animal models of poliomyelitis lesions may generate hypotheses on sensory symptoms; leaves open translation to human disease.
THE PATIENT with acute poliomyelitis is often much more concerned with the pain of the disease than he is with the paralysis. Patients have been known to remain awake for an entire week as a result of the pain, yet, despite the importance of this symptom in poliomyelitis, little is known of its cause. One of us (A. C. G.)1was the victim of a severe attack of poliomyelitis in 1946. Since that time animal experiments, to be described in the present paper, have been conducted in an attempt to correlate experimentally induced lesions with the sensory disturbances of the disease. Clinicians have known for many years that there are several types of pain in poliomyelitis.2In the early stages of the acute disease the patient usually has severe headache. At the same time he has severe pain in the lower part of the back, and he may
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Arthur C. Guyton (1950) studied Acute poliomyelitis. Experimentally induced lesions was evaluated on Sensory disturbances. Experimentally induced lesions were investigated in animal models to correlate with sensory disturbances of poliomyelitis, with no quantitative results reported in the truncated abstract.
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