In situ condensation of an anti-cancer drug into fibrin gel enabling effective inhibition of tumor cell growth

Masayasu Kuwahara; Hiroto Fujita; Yuka Kataoka; Yasuyo Nakajima; Masanobu Yamada; Naoki Sugimoto

doi:10.1039/c9cc06418d

January 1, 2019Chemical Communications

In situ condensation of an anti-cancer drug into fibrin gel enabling effective inhibition of tumor cell growth

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Key Points

To evaluate the efficacy of localized tumor cell growth inhibition using a fibrin polymer gel loaded with a camptothecin derivative via aptamer-assisted in situ condensation.
Engineered an in situ polymerizing fibrin hydrogel incorporating a camptothecin (CPT) derivative.
Applied carrier aptamers to convey and concentrate the chemotherapeutic agent into the gel matrix via selective oligonucleotide entrapment in fibrin polymers (SOEF).
Assessed the inhibitory effect of the drug-entrapped fibrin polymer gel on tumor cell proliferation.
Achieved efficient conveyance and condensation of the camptothecin derivative from liquid solution directly into the forming fibrin gel matrix via the SOEF mechanism.
Observed highly effective inhibition of tumor cell growth mediated by the drug-loaded fibrin polymer hydrogel.

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Implication

Experimental study demonstrates potent inhibition of tumor cell growth via aptamer-mediated camptothecin condensation in fibrin gels, suggesting a novel localized chemotherapy delivery strategy.

Abstract

We show herein the highly effective inhibition of tumor cell growth using a gel consisting of a fibrin polymer formed with the in situ condensation of a camptothecin (CPT) derivative as an anti-cancer drug, which is efficiently conveyed with a carrier aptamer from a solution to the gel in a phenomenon, called selective oligonucleotide entrapment in fibrin polymers (SOEF).

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Kuwahara et al. (2019) studied this question.

synapsesocial.com/papers/6a9a73511ef9f7a65aa21078 https://doi.org/10.1039/c9cc06418d

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In situ condensation of an anti-cancer drug into fibrin gel enabling effective inhibition of tumor cell growth

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

In situ condensation of an anti-cancer drug into fibrin gel enabling effective inhibition of tumor cell growth

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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