Antihyperglycemic activity of Caralluma fimbriata: An In vitro approach

OBJECTIVE: . MATERIALS AND METHODS: were subjected to alpha-amylase and alpha-glucosidase inhibitory assay with acarbose as control. Cytotoxicity was assessed by 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Glucose uptake assay was performed on L6 myotubes using the extract in 1 μg-100 μg/mL, using metformin and insulin as control. RESULTS: of extract and metformin was found to be ≥1000 μg/mL and ≥1000 μM, respectively, in the cell line tested. CONCLUSION: has promising antihyperglycemic activity. SUMMARY: GLUT: Glucose transporter; MTT: 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide.