Key result
Aortic valve-sparing procedures in patients with Marfan syndrome resulted in 0 deaths and 0 valve-related complications over a mean follow-up of 46 months, with 2 patients requiring reoperation.
Why the study?
Do aortic valve-sparing operations provide durable outcomes in patients with Marfan syndrome and aortic root aneurysm?
Observational (n=20)
Do aortic valve-sparing operations provide durable outcomes in patients with Marfan syndrome and aortic root aneurysm?
Aortic valve-sparing operations demonstrate favorable early and mid-term durability in patients with Marfan syndrome and aortic root aneurysm.
Answers are grounded in this paper and cite their sources.
Supports valve-sparing surgery in Marfan syndrome; hypothesis-generating and requires validation in larger prospective studies.
BACKGROUND: We report our experience with aortic valve-sparing procedures in patients with Marfan syndrome and aortic root aneurysm. METHODS: Between August 2003 and July 2007, we performed aortic valve-sparing procedures in 20 patients with aortic root aneurysm resulting from Marfan syndrome. Mean age was 28 +/- 10 years (range, 10 to 57 years), and there were 9 females and 11 males. A reimplantation technique was used in 9 cases, a remodeling technique in 8 and a patch technique in 3 cases. Additional procedures included total aorta replacement in 1 patient, and aortic arch replacement plus stented elephant trunk in 2 patients. The mean follow-up time was 46 +/- 16 months (range, 17 to 64 months). RESULTS: No in-hospital or late death occurred. Reexploration for bleeding was required in one case on postoperative day 1. No valve-related complications occurred during the follow-up period. At the end of follow-up, trivial or no aortic regurgitation was demonstrated in 14 patients, mild in 4 patients, moderate in 1 and severe in 1. Two patients with moderate and severe aortic regurgitation required reoperation. CONCLUSIONS: The early and mid-term results of the valve-sparing operations were favorable, and the durability of the preserved valve should encourage use of this technique in patients with Marfan syndrome.
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Wang et al. (2010) conducted an observational in Marfan syndrome and aortic root aneurysm (n=20). Aortic valve-sparing procedures was evaluated on In-hospital or late death, valve-related complications, and aortic regurgitation. Aortic valve-sparing procedures in patients with Marfan syndrome resulted in 0 deaths and 0 valve-related complications over a mean follow-up of 46 months, with 2 patients requiring reoperation.
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