Crosslinking strategies govern the morphology and biological performance of decellularized extracellular matrix particle–tyramine-modified hyaluronic acid hydrogels

This is the authors' abstract. We don't add key points for this paper.

ratio from FTIR analysis, clear morphological changes in confocal microscopy, higher glycosaminoglycan (GAG) and collagen retention, as well as slower GAG and collagen release. HRP/Eo-dECM hydrogels promoted stronger gene expression of type II collagen (COL2) and higher compressive modulus compared with SPS/Ru-dECM hydrogels. In summary, HRP/Eo crosslinked dECM hydrogels demonstrated improved mechanical performance and chondrocyte redifferentiation effect compared to SPS/Ru, attributed to the difference in hydrogel morphology. These findings identify the HRP/Eo crosslinking method as a favorable strategy for engineering dECM particle-THA hydrogels for cartilage regeneration.