Key result
Combined atrial fibrillation ablation and left atrial appendage closure is a safe, effective, and cost-effective option for patients with symptomatic AF and high risk of stroke and/or bleeding.
Why the study?
Combined AF ablation and left atrial appendage closure is practiced to manage symptoms and high stroke risk, prompting a review of recent evidence regarding the combined procedure.
Does combined atrial fibrillation ablation and left atrial appendage closure improve outcomes in patients with symptomatic AF and high stroke/bleeding risk?
Does combined atrial fibrillation ablation and left atrial appendage closure improve outcomes in patients with symptomatic AF and high stroke/bleeding risk?
Combined AF ablation and LAAC is a promising, safe, and cost-effective option for patients with symptomatic AF and high stroke/bleeding risk.
Answers are grounded in this paper and cite their sources.
Combined AF ablation and LAAC appears feasible long-term; leaves open randomized confirmation of net clinical benefit.
PURPOSE OF REVIEW: Combined atrial fibrillation (AF) ablation and left atrial (LA) appendage (LAA) closure (LAAC) has been practiced for management of both the symptoms and the high stroke risk of AF. The purpose of this review is to review recent evidence regarding the combined procedure. RECENT FINDINGS: Newly acquired long-term data of combined AF ablation and LAAC supplied satisfactory evidence on the safety and efficacy of the combined procedure. Studies also showed LA structural remodeling following combined procedure was mainly affected by sinus rhythm status post catheter ablation, not by LAAC. A cost-effectiveness study revealed that combined procedure was a cost-effective therapeutic option in symptomatic AF patients with high stroke and bleeding risk. Due to recent evidence of high incidences of LAA thrombus formation after LAA electrical isolation (LAAEI) and benefit of LAAC after LAAEI, an extended combined procedure of standard AF ablation plus LAAEI and LAAC was considered as a potential therapeutic option for persistent AF patients with high stroke risk. SUMMARY: In conclusion, combined AF ablation and LAAC serve as a promising option for patients with symptomatic AF and high risk of stroke and/or bleeding.
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A 2021 study conducted a review in Atrial fibrillation. Combined atrial fibrillation ablation and left atrial appendage closure was evaluated. Combined atrial fibrillation ablation and left atrial appendage closure is a safe, effective, and cost-effective option for patients with symptomatic AF and high risk of stroke and/or bleeding.
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