Key result
Symptomatic patients after Roux-en-Y gastric bypass had higher peak glucose values during OGTT compared to asymptomatic patients (236 vs 189 mg/dL; P<0.05), with faster glucose increase and decline.
Why the study?
The study was conducted to evaluate glucose and insulin profiles during an oral glucose tolerance test after Roux-en-Y gastric bypass in symptomatic versus asymptomatic patients.
Do glucose and insulin dynamics during OGTT differ between patients with and without hypoglycemia symptoms after Roux-en-Y gastric bypass?
Population
27 symptomatic and 99 asymptomatic patients who underwent Roux-en-Y gastric bypass
Comparison
Symptomatic patients tested at presentation vs asymptomatic patients tested 1 year post-RYGB
Design
Retrospective study
Authors
Loading...
Symptom status may refine post-RYGB OGTT interpretation; leaves open whether insulin profiles predict outcomes or guide therapy.
Observational (n=126)
Do glucose and insulin dynamics during OGTT differ between patients with and without hypoglycemia symptoms after Roux-en-Y gastric bypass?
Absolute Event Rate: 236% vs 189%
p-value: p=<0.05
In patients after Roux-en-Y gastric bypass, the speed of glucose and insulin changes during OGTT, rather than absolute minimum glucose values, differentiates those with hypoglycemia symptoms from asymptomatic patients.
Mariën et al. (2020) conducted an observational in Roux-en-Y gastric bypass (n=126). Hypoglycaemia symptoms vs. Asymptomatic patients was evaluated on Peak glucose values during OGTT (p=<0.05). Symptomatic patients after Roux-en-Y gastric bypass had higher peak glucose values during OGTT compared to asymptomatic patients (236 vs 189 mg/dL; P<0.05), with faster glucose increase and decline.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: