Therapeutic drug monitoring of sertraline and clinical response

Q: What does this research mean for the field?

Variability in sertraline exposure and clinical response is influenced by patient-specific factors and can be evaluated using therapeutic drug monitoring. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Y. W. Francis Lam

doi:10.1002/pu.31496

September 2, 2026The Brown University Psychopharmacology Update

Therapeutic drug monitoring of sertraline and clinical response

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Key Points

To examine how therapeutic drug monitoring and pharmacokinetic variability influence individual clinical response to sertraline and other psychotropics.
Assessed patient-specific determinants of drug exposure, including age, sex, metabolic capacity, adherence, and drug-drug interactions.
Reviewed clinical applications of therapeutic drug monitoring using serum drug concentration measurements to evaluate therapeutic response.
Therapeutic drug monitoring provides an established approach to identify whether varying drug concentrations correlate with differences in therapeutic response.
Patient-level factors substantially alter systemic drug exposure, requiring personalized exposure assessments rather than reliance on standard dosing alone.

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Implication

Narrative review highlights therapeutic drug monitoring for sertraline, indicating blood level tracking explains variability in patient response.

Abstract

Variability in drug exposure and response among individual patients can occur because of numerous factors, including age, sex, metabolic capacity, medication adherence, and the presence and magnitude of interactions with concurrently administered drugs. For decades, therapeutic drug monitoring with drug concentration determinations has been used to evaluate whether variability in drug exposure might be related to significant differences in therapeutic response to psychotropics (Hart et al., 2024; Kang & Lee, 2009).

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Y. W. Francis Lam (2026) studied this question.

synapsesocial.com/papers/6a9a85e75d9e33f25c6314b1 https://doi.org/10.1002/pu.31496

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Therapeutic drug monitoring of sertraline and clinical response

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Implication

Abstract

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Therapeutic drug monitoring of sertraline and clinical response

Key Points

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Implication

Abstract

Discussion

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