In vitro experimental evaluation demonstrates label-free prostate-specific antigen detection with low temperature drift, indicating strong viability for point-of-care diagnostics.
Silicon‐based optical biosensors are increasingly employed in diverse applications, yet their practical deployment is constrained by ambient temperature fluctuations and single‐use format. Here we report a reusable silicon photonic biosensor based on a temperature‐insensitive Mach–Zehnder interferometer (MZI) architecture. The device exhibits a high bulk sensitivity of 431.9 nm/RIU while maintaining an ultralow temperature sensitivity of 4.45 pm/°C. A stable Parylene C coating enables antibody immobilization for specific antigen capture on the sensor surface. Captured antigen can be rapidly removed using a diluted HCl solution, allowing efficient sensor regeneration. The biosensor demonstrates label‐free detection of prostate‐specific antigen (PSA) in blood samples with a limit of detection (LOD) of 0.45 pg/mL and recovery rates of 96.82%–112.93%. These results highlight the potential of our MZI‐based platform for practical point‐of‐care testing.
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Su et al. (2026) studied this question.
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