Key result
Repetitive transcranial magnetic stimulation resulted in a ≥50% reduction of auditory hallucinations in 37.5% (3 of 8) of patients with severe schizophrenia and significantly increased sympathetic modulation.
Why the study?
Does repetitive transcranial magnetic stimulation reduce auditory hallucinations and affect cardiac autonomic function in patients with severe schizophrenia?
Observational (n=8)
Does repetitive transcranial magnetic stimulation reduce auditory hallucinations and affect cardiac autonomic function in patients with severe schizophrenia?
rTMS may offer partial efficacy for auditory hallucinations in severe schizophrenia but is associated with an acute increase in sympathetic autonomic modulation.
May indicate partial rTMS benefit with sympathetic activation in severe schizophrenia; leaves open efficacy and safety pending controlled trials.
Repetitive transcranial magnetic stimulation (rTMS) has been reported to be an effective treatment for auditory hallucination (AH) in schizophrenia patients. The efficacy of rTMS and immediate changes in cardiac autonomic function (CAF) after rTMS in severe schizophrenia patients with AH (n = 8) were investigated. Three patients reported a >or=50% reduction of AH after rTMS. The ratio of low-frequency power to high-frequency power, an index of sympathetic modulation, increased significantly after rTMS. Further replication studies with larger sample sizes are indicated.
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Lai et al. (2010) conducted an observational in Severe schizophrenia with auditory hallucination (n=8). Repetitive transcranial magnetic stimulation (rTMS) was evaluated on ≥50% reduction of auditory hallucination (AH). Repetitive transcranial magnetic stimulation resulted in a ≥50% reduction of auditory hallucinations in 37.5% (3 of 8) of patients with severe schizophrenia and significantly increased sympathetic modulation.
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