Key result
Calibrated automated thrombography correlated significantly with prothrombin (r=0.295, P<0.01) and tissue factor pathway inhibitor (r=-0.480, P<0.01), better reflecting coagulation status than aPTT.
Why the study?
Does calibrated automated thrombography more accurately determine coagulation status compared to standard global coagulation assays in pediatric patients with congenital heart disease?
Observational (n=60)
Does calibrated automated thrombography more accurately determine coagulation status compared to standard global coagulation assays in pediatric patients with congenital heart disease?
Effect estimate: r = 0.295
p-value: p=<0.01
Calibrated automated thrombography may determine thrombin generation more accurately than standard global coagulation assays in pediatric patients with congenital heart disease.
Hypothesis-generating for calibrated automated thrombography in pediatric congenital heart disease; prospective validation needed before clinical adoption.
The aim of this study was to investigate the possible suitability of the calibrated automated thrombography to determine the coagulation status of pediatric patients with congenital heart disease. Thrombin generation was measured in 60 patients with congenital heart disease using the calibrated automated thrombography and compared to data using standard coagulation parameters such as prothrombin, antithrombin, tissue factor pathway inhibitor, prothrombin fragment 1.2 (F 1.2), and activated partial thromboplastin time. A significant positive correlation was observed between prothrombin and the endogenous thrombin potential (P < 0.01; r = 0.295) as well as between prothrombin and peak height (P < 0.01; r = 0.581). A significant negative correlation was seen between tissue factor pathway inhibitor and endogenous thrombin potential (P < 0.01; r = -0.480) and between tissue factor pathway inhibitor and peak height (P < 0.01; r = -0.234). No statistically significant correlation was found between antithrombin and parameters of continuous thrombin generation. Significant correlation was seen neither between activated partial thromboplastin time and F1.2 nor between activated partial thromboplastin time and prothrombin. The data presented here indicate that calibrated automated thrombography measurements determine thrombin generation more accurately and therefore reflect better the coagulation status of pediatric patients with congenital heart disease then standard global coagulation assays such as activated partial thromboplastin time.
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Rosenkranz et al. (2008) conducted an observational in Congenital heart disease (n=60). Calibrated automated thrombography vs. Standard coagulation parameters was evaluated on Correlation between standard coagulation parameters and thrombin generation (r = 0.295, p=<0.01). Calibrated automated thrombography correlated significantly with prothrombin (r=0.295, P<0.01) and tissue factor pathway inhibitor (r=-0.480, P<0.01), better reflecting coagulation status than aPTT.
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