Key result
Norepinephrine precipitated ventricular arrhythmias in cats and had greater potency than epinephrine in eliciting automatic contractile activity in isolated papillary muscles.
Norepinephrine induces ventricular arrhythmias in a feline model and exhibits greater potency than epinephrine in stimulating automaticity in isolated papillary muscles.
Suggests catecholamine-specific arrhythmia risks in animal models; leaves open translation to human ventricular arrhythmias.
(1) Nodal rhythm, ventricular extrasystoles, flutter and fibrillation were precipitated by norepinephrine in cats, under pentobarbital anesthesia, treated with harman methosulfate. Migration of the T-wave into the R-wave at onset of ventricular fibrillation was similar to that described before epinephrine induced arrhythmias. (2) The effects of norepinephrine on cardiac excitability were confirmed using isolated papillary muscles in which norepinephrine had a greater potency than epinephrine in eliciting automatic contractile activity.
No takes yet. Share an insight, caveat, or question.
Duncan E. Hutcheon (1956) studied Ventricular arrhythmias. Norepinephrine vs. Epinephrine was evaluated on Precipitation of ventricular arrhythmias and automatic contractile activity. Norepinephrine precipitated ventricular arrhythmias in cats and had greater potency than epinephrine in eliciting automatic contractile activity in isolated papillary muscles.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: