Key result
Pre-operative administration of magnesium sulfate did not significantly reduce postoperative pain severity or opioid consumption compared to normal saline in patients undergoing lumbar fusion surgery.
Why the study?
Reducing postoperative pain can improve patient satisfaction and hospital costs, and intravenous magnesium sulfate has been proposed as an agent for preemptive analgesia.
Does pre-operative magnesium sulfate reduce postoperative pain in patients undergoing lumbar fusion surgery?
RCT (n=102)
Double-blind
Computer-generated randomization table
No
Does pre-operative magnesium sulfate reduce postoperative pain in patients undergoing lumbar fusion surgery?
Pre-operative administration of a single dose of magnesium sulfate does not significantly reduce postoperative pain or opioid consumption in patients undergoing lumbar fusion surgery.
Answers are grounded in this paper and cite their sources.
Preoperative magnesium sulfate yields no pain or opioid reduction after lumbar fusion; challenges preemptive analgesia hypothesis and directs research to alternatives.
BackgroundReducing postoperative pain can improve patient satisfaction and hospital cost. Intravenous magnesium sulfate is one of the proposed drugs for preemptive analgesia. The study aimed to evaluate the effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgery.MethodsA double-blind randomized clinical trial was conducted on candidates for vertebral fusion surgery with American Society of Anesthesiologists (ASA) class I-II. One hundred and two patients were randomized into the magnesium sulfate group and control group. The magnesium sulfate group received magnesium sulfate at a dose of 50mg/kg in 20 mL volume and infused during 15-30 minutes pre-operation, while the control group received 20 mL normal saline. The severity of the pain was assessed by the Visual Analogue Scale (VAS) at 2, 4, 6, 12 and 24 hours after patients entering the post-anesthetic care unit. After the operation, the patients’ relaxation rate was assessed based on Ramsay sedation score (RSS).ResultsThere was no significant difference at 2, 4, 6, 12 and 24 hours post-operation between the two groups in the mean severity of pain (p>0.05). There was no significant difference at 2, 4, 6, 12 and 24 hours post-operation between the two groups in the mean of pethidine consumption. There was no significant difference in the relaxation of the patients according to the RSS criteria in the magnesium sulfate and control groups (p=0.162). ConclusionPre-operative administration of magnesium sulfate does not affect reduction in postoperative pain and opioid consumption of patients undergoing lumbar fusion surgery.
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Delavari et al. (2019) conducted an RCT in Lumbar fusion surgery (n=102). Magnesium sulfate vs. 20 mL normal saline was evaluated on Severity of postoperative pain assessed by Visual Analogue Scale (VAS) at 2, 4, 6, 12, and 24 hours (p=>0.05). Pre-operative administration of magnesium sulfate did not significantly reduce postoperative pain severity or opioid consumption compared to normal saline in patients undergoing lumbar fusion surgery.
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