Original Articles: Prostate Cancer: Deoxyribonucleic Acid Ploidy Analysis as a Predictor of Recurrence Following Radical Prostatectomy for Stage T2 Disease

No AccessJournal of UrologyClinical Urology: Original Article1 Mar 1995Original Articles: Prostate Cancer: Deoxyribonucleic Acid Ploidy Analysis as a Predictor of Recurrence Following Radical Prostatectomy for Stage T2 Disease Marne J. CarMichael, Robert W. Veltri, Alan W. Partin, M. Craig Miller, Patrick C. Walsh, and Jonathan I. Epstein Marne J. CarMichaelMarne J. CarMichael More articles by this author , Robert W. VeltriRobert W. Veltri More articles by this author , Alan W. PartinAlan W. Partin More articles by this author , M. Craig MillerM. Craig Miller More articles by this author , Patrick C. WalshPatrick C. Walsh More articles by this author , and Jonathan I. EpsteinJonathan I. Epstein More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67625-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Deoxyribonucleic acid (DNA) ploidy image analysis was used postoperatively to predict recurrence of 112 clinically localized adenocarcinomas of the prostate. All men underwent radical retropubic prostatectomy between 1978 and 1991. Patients with positive lymph nodes or positive seminal vesicles were excluded because progression is nearly inevitable in these men. The minimum followup for men without progression was 5 years (range 5 to 15). Patients were considered to have clinically evident disease progression based on local recurrence (8%), distant metastases (4%) and/or an isolated elevation of serum prostate specific antigen (87%). Of the tumors 43% were diploid and 57% were nondiploid. In a multivariate analysis comparing grade, ploidy, capsular penetration and surgical margins, Gleason sum was the best predictor of progression (p <0.0001). Nevertheless, a subset of patients remained with well to moderately differentiated Gleason grade tumors (Gleason sum 6 or less) who failed. DNA ploidy was able to predict recurrence in this particular group (p = 0.034). In addition, we compared different methods of tissue preparation to determine which best predicted progression. We found that ploidy analysis on tissue sections was more predictive than ploidy performed on disaggregated tissue. In summary, our study revealed that DNA ploidy analysis can offer additional prognostic information following radical prostatectomy for men with low grade prostatic adenocarcinoma. References 1 : Correlation of pathologic findings with progression after radical retropubic prostatectomy. Cancer1993; 71: 3582. Google Scholar 2 : Serum PSA after anatomic radical prostatectomy. 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Link, Google Scholar From the Departments of Pathology and Urology, The Johns Hopkins University School of Medicine and the James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland and Cytodiagnostics, Inc., Oklahoma City, Oklahoma© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBRINKER D, ROSS J, TRAN T, JONES D and EPSTEIN J (2018) CAN PLOIDY OF PROSTATE CARCINOMA DIAGNOSED ON NEEDLE BIOPSY PREDICT RADICAL PROSTATECTOMY STAGE AND GRADE?Journal of Urology, VOL. 162, NO. 6, (2036-2039), Online publication date: 1-Dec-1999.O'Dowd G, Veltri R, Orozco R, Miller M and Oesterling J (2018) Update on the Appropriate Staging Evaluation for Newly Diagnosed Prostate CancerJournal of Urology, VOL. 158, NO. 3, (687-698), Online publication date: 1-Sep-1997.Erbersdobler A, Hammerer P, Huland H and Henke R (2018) NUMERICAL CHROMOSOMAL ABERRATIONS IN TRANSITION-ZONE CARCINOMAS OF THE PROSTATEJournal of Urology, VOL. 158, NO. 4, (1594-1598), Online publication date: 1-Oct-1997.Badalament R, Craig M, Peller P, Young D, Bahn D, Kochie P, O'Dowd G and Veltri R (2018) An Algorithm for Predicting Nonorgan Confined Prostate Cancer Using the Results Obtained from Sextant Core Biopsies with Prostate Specific Antigen LevelJournal of Urology, VOL. 156, NO. 4, (1375-1380), Online publication date: 1-Oct-1996.Lerner S, Blute M, Bergstralh E, Bostwick D, Eickholt J and Zincke H (2018) Analysis of Risk Factors for Progression in Patients with Pathologically Confined Prostate Cancers After Radical Retropubic ProstatectomyJournal of Urology, VOL. 156, NO. 1, (137-143), Online publication date: 1-Jul-1996. Volume 153Issue 3SMarch 1995Page: 1015-1019 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information Marne J. CarMichael More articles by this author Robert W. Veltri More articles by this author Alan W. Partin More articles by this author M. Craig Miller More articles by this author Patrick C. Walsh More articles by this author Jonathan I. Epstein More articles by this author Expand All Advertisement PDF downloadLoading ...