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The administration to mice of Cortisone in doses approximately 50 times the dose for humans produced a striking lymphopenia, loss in body weight, atrophy of thymus and spleen, and diminution in size of adrenal cortex, salivary glands, pituitary, and hibernating fat bodies. A number of histologic changes are briefly described.
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W. Antopol (1950) studied this question.
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