The Sensitized Sheep Cell Agglutination Reaction in Rheumatoid Arthritis

Editorial1 June 1956THE SENSITIZED SHEEP CELL AGGLUTINATION REACTION IN RHEUMATOID ARTHRITISJOHN T. SHARPJOHN T. SHARPSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-6-1270 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMarked enhancement of various agglutination reactions by non-immune serum was occasionally reported during the early decades of the present century, but the possible clinical significance of this phenomenon was not recognized until 1940 when Waaler1reported that approximately 35% of sera from patients with rheumatoid arthritis possessed such a property in contrast to less than 5% of a control series. Perhaps as a result of the intervention of the war, this work was completely lost sight of until the phenomenon was rediscovered by Rose and coworkers2who found significant enhancement of agglutination by 80% of rheumatoid sera as compared with...1 Waaler E: On occurrence of factor in human serum activating specific agglutination of sheep blood corpuscles, Acta path. et microbiol. Scandinav. 17: 172-188, 1940. CrossrefGoogle Scholar2 RoseRaganPearceLopman HMCEMO: Differential agglutination of normal and sensitized sheep erythrocytes by sera of patients with rheumatoid arthritis, Proc. Soc. Exper. Biol. and Med. 68: 1-6, 1948. CrossrefMedlineGoogle Scholar3 Ball J: Sheep cell agglutination test for rheumatoid arthritis—a clinico-pathological study, Ann. Rheumat. Dis. 11: 97-111, 1952. CrossrefMedlineGoogle Scholar4 SvartzSchlossmann NK: The hemagglutination test with sensitized sheep cells in rheumatoid arthritis and some other diseases, Acta med. Scandinav. 142: 420-432, 1952. CrossrefMedlineGoogle Scholar5 BrownBunimMcEwen RJJC: Differential sheep-cell agglutination test in rheumatoid arthritis, Ann. Rheumat. Dis. 8: 299-301, 1949. CrossrefMedlineGoogle Scholar6 Winblad S: Studies on agglutination of sensitized sheep cells in rheumatic diseases. I. Agglutination titer after primary absorption of serum by sheep cells, Acta med. Scandinav. 142: 450-457, 1952. CrossrefMedlineGoogle Scholar7 HellerJacobsonKolodnyKammerer GASMHWH: The hemagglutination test for rheumatoid arthritis. II. The influence of human plasma fraction II (gamma globulin) on the reaction, J. Immunol. 72: 66-78, 1954. MedlineGoogle Scholar8 PikeSulkinCoggeshallBurdette RMSEHCRI: Serological reactions in rheumatoid arthritis. IV. Persistence of the serum factor which agglutinates sensitized sheep cells, J. Lab. and Clin. Med. 41: 880-886, 1953. MedlineGoogle Scholar9 MillerLynchLansbury JEERJ: Failure of sensitized sheep cell agglutination to clarify the diagnosis of rheumatic disease, J. Lab. and Clin. Med. 34: 1216-1221, 1949. MedlineGoogle Scholar10 Wager O: On the factor producing agglutination of sensitized red cells and its relation to the agglutination of hemolytic streptococci in rheumatoid arthritis sera, Ann. med. exper. et biol. Fenniae 28: Suppl. 8, 1950. Google Scholar11 Ball J: Personal communication. Google Scholar12 ZiffBrownBadinMcEwen MPJC: A hemagglutination test for rheumatoid arthritis with enhanced sensitivity using the euglobulin fraction, Bull. Rheum. Dis. 5: 75-76, 1954. MedlineGoogle Scholar13 Lamont-Havers RW: Nature of serum factors causing agglutination of sensitized sheep cells and group A hemolytic streptococci, Proc. Soc. Exper. Biol. and Med. 88: 35, 1955. CrossrefMedlineGoogle Scholar14 Winblad S: Studies on agglutination of sensitized sheep cells in rheumatic diseases. II. On the nature of the agglutinating serum factor, Acta med. Scandinav. 142: 458-467, 1952. CrossrefMedlineGoogle Scholar15 HobsonGorrill DRH: Agglutination test for rheumatoid arthritis, Lancet 1: 389-391, 1952. CrossrefMedlineGoogle Scholar16 PikeSulkinCoggeshall RMSEHC: Serological reactions in rheumatoid arthritis. II. Concerning the nature of the factor in rheumatoid-arthritis serum responsible for increased agglutination of sensitized sheep erythrocytes, J. Immunol. 63: 447-463, 1949. MedlineGoogle Scholar17 Vaughn JH: Behavior of the agglutination activating factor of rheumatoid arthritis with immune precipitates, Ann. Rheumat. Dis. 14: 431, 1955. Google Scholar18 EpsteinJohnsonRagan WAMC: Proc. Soc. Exper. Biol. and Med. In press. Google Scholar19 GorrillHobson RHD: The agglutinating property of complement, J. Path. and Bact. 64: 257-263, 1952. CrossrefMedlineGoogle Scholar20 DavisKabatHarrisMoore BDEAADH: The anticomplementary activity of serum gamma globulin, J. Immunol. 49: 223-233, 1944. Google Scholar21 FischelPauliLesh EERHJ: Serological studies in rheumatic fever. II. Serum complement in the rheumatic state, J. Clin. Investigation 28: 1172-1181, 1949. CrossrefGoogle Scholar22 FischelGajdusek EEDC: Serum complement in acute glomerulonephritis and other renal diseases, Am. J. Med. 12: 190-196, 1952. CrossrefMedlineGoogle Scholar23 WedgewoodJaneway RJCA: Serum complement in children with "collagen diseases," Pediatrics 11: 569-581, 1953. MedlineGoogle Scholar24 VaughnBaylesFavour JHTBCB: Serum complement in rheumatoid arthritis, Am. J. M. Sc. 222: 186-192, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLatex-Fixation Test in Rheumatoid ArthritisCOMPLEMENT, COMPLEMENT COMPONENTS, PROPERDIN AND AGGLUTINATION PROMOTING FACTORS IN RHEUMATOID ARTHRITISA Relationship Between Blood Group Serology and Rheumatoid Arthritis Serology. Serum Protein Groups 1 June 1956Volume 44, Issue 6Page: 1270-1275KeywordsRheumatoid arthritis Issue Published: 1 June 1956 PDF DownloadLoading ...