Because of sleep alterations in schizophrenia, 4 schizophrenic patients were studied to evaluate sleep-associated GH release. The GH night pattern was studied for 2 consecutive nights using a continuous blood sampling procedure, with simultaneous EEG, EOG, and EMG scoring. Sleep-related GH secretion was impaired in 3 out of 4 patients. No close correlation was evident between EEG sleep stages and GH secretion. Finally, correlations between biogenic amine disturbances in schizophrenia and GH night release impairment are discussed.
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Vigneri et al. (2008) studied this question.