Key result
Physical exercise significantly reduced plasma concentrations of ADMA (0.68 vs 0.48 µmol/L) and SDMA (0.45 vs 0.30 µmol/L) and increased L-arginine levels (44.20 vs 74.13 µmol/L) in patients with coronary artery disease.
Why the study?
Does a single session of physical exercise improve plasmatic levels of ADMA, SDMA, and L-ARG in patients with stable coronary artery disease?
Observational (n=30)
No
Does a single session of physical exercise improve plasmatic levels of ADMA, SDMA, and L-ARG in patients with stable coronary artery disease?
A single session of physical exercise significantly reduces plasma levels of ADMA and SDMA and increases L-arginine in patients with stable CAD, suggesting a mechanism for exercise-induced improvement in endothelial function.
Acute exercise improved arginine-NO metabolites in CAD; hypothesis-generating for endothelial benefits, needs randomized confirmation.
Increased levels of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and low plasma level of L-arginine (L-ARG) are all conditions likely to decrease nitric oxide (NO) production. Aim of this study is to evaluate ADMA, SDMA, and L-ARG plasmatic levels before and after physical exercise in patients with coronary artery disease (CAD). We studied 30 patient with mean age 52 + 4.5 years. After inclusion in the study, before the execution of physical exercise, heparinized blood sample was drawn from an indwelling arterial line for determination of ADMA, L-ARG and SDMA (baseline values). Subsequently a blood sample was drawn after the physical exercise. The mean plasma concentrations of ADMA (0.68 + 0.06 vs 0.48 + 0.05 µmol/L) and SDMA (0.45 + 0.03 vs 0.30 + 0.03 µmol/L) were significantly lower after physical exercise in comparison to baseline value, while L-ARG mean levels were increased (44.20 + 10.5 vs 74.13 + 11.2 µmol/L). Physical exercise has a beneficial effect by reducing plasmatic ADMA and SDMA levels, and increasing L-ARG substrate for endothelial NO.
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Graziano Riccioni (2015) conducted an observational in Coronary artery disease (n=30). Physical exercise vs. Baseline (pre-exercise) was evaluated on Plasma concentration of ADMA (µmol/L) (p=<0.001). Physical exercise significantly reduced plasma concentrations of ADMA (0.68 vs 0.48 µmol/L) and SDMA (0.45 vs 0.30 µmol/L) and increased L-arginine levels (44.20 vs 74.13 µmol/L) in patients with coronary artery disease.
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