Key result
Serum Lipoprotein(a) levels in Japanese children with insulin-dependent diabetes mellitus averaged 16.7 mg/dl and were significantly correlated with atherogenic index and apolipoprotein B.
Cross-Sectional (n=48)
In Japanese children with IDDM, serum Lp(a) levels are comparable to normal children and correlate with atherogenic lipid profiles rather than glycemic control.
We studied serum lipoprotein (a) (Lp (a)) levels in 48 Japanese children with insulin-dependent-diabetes mellitus (IDDM). The subjects were on average 12.5±0.6 (SEM) years old, the duration of diabetes was 4.3±0.5 years, the insulin was 1.05±0.05U/kg, and the HbAlc was 7.91±0.22%. Serum Lp (a) was 16.7±2.6mg/dl (range, 0.6∼66.5mg/dl), the geometric mean level of Lp (a) was 9.2mg/dl, and 27.1% of the patients had Lp (a) levels that were more than 17mg/dl. Serum Lp (a) was not related to fasting plasma glucose, plasma fructosamine or HbAlc. Furthermore, serum Lp (a) was not significantly related to age, gender, duration, body mass index, urinary C-peptide or albumin excretions. Serum Lp (a) was not related to fasting plasma glucose, plasma fructosamine or HbAlc. However, serum Lp (a) was significantly related to the atherogenic index, apolipoprotein B/A1 (p<0.05), and apolipoprotein B (p<0.005). These results indicat that serum Lp (a) levels in Japanese children with IDDM do not differ from the values for normal children reported in the literature.
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Yamamoto et al. (1993) conducted a cross-sectional in Insulin-dependent diabetes mellitus (IDDM) (n=48). Insulin-dependent diabetes mellitus vs. Normal children (literature values) was evaluated on Serum Lipoprotein(a) levels. Serum Lipoprotein(a) levels in Japanese children with insulin-dependent diabetes mellitus averaged 16.7 mg/dl and were significantly correlated with atherogenic index and apolipoprotein B.
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