Why the study?
Does intravenous metoclopramide increase QT dynamicity in healthy male volunteers?
Population
10 healthy male volunteers
Comparison
Metoclopramide 10 mg administered intravenously vs Placebo administered intravenously
Design
RCT, at random, double-blind
Follow-up
30 minutes post-administration
Key result
Intravenous metoclopramide significantly increased the QT/RR slope (0.064 vs 0.037 pre-drug; P=0.041) and QT variance (P=0.023) in healthy male volunteers.
Authors
Loading...
IV metoclopramide warrants arrhythmia caution in clinical use; extends mechanistic evidence linking it to ventricular arrhythmia risk.
RCT (n=10)
Double-blind
Randomized
Does intravenous metoclopramide increase QT dynamicity in healthy male volunteers?
Absolute Event Rate: 0.064% vs 0.05%
p-value: p=0.041
Intravenous metoclopramide increases QT dynamicity in healthy male volunteers, providing a potential mechanistic explanation for its associated risk of ventricular arrhythmias.
Ellidokuz et al. (2003) conducted an RCT in Healthy volunteers (n=10). Metoclopramide vs. Placebo was evaluated on QT/RR slope (p=0.041). Intravenous metoclopramide significantly increased the QT/RR slope (0.064 vs 0.037 pre-drug; P=0.041) and QT variance (P=0.023) in healthy male volunteers.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: