Experimental study demonstrates direct cyclization of allenyl aldehydes using organozinc reagents, indicating a versatile route to stereochemically defined alkenes.
The direct cyclization of allenyl aldehydes with organozincs in the presence of Ni(COD)(2) provides synthetically versatile homoallylic alcohols. Both monosubstituted and 1,3-disubstituted allenes participate in the process, with the latter allowing preparation of stereochemically defined trisubstituted alkenes. [reaction: see text]
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Montgomery et al. (2002) studied this question.
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