Qualitative systematic reviews to increase the volume and diversity of patient perspectives included in the development of core outcome sets. Tuberculosis: a pilot study

Patient involvement is a core value of contemporary healthcare, and an emerging component of core outcome set (COS) methodology. This project pilots the use of qualitative systematic reviews of patient perspectives on outcome prioritisation in COS development, specifically for a COS for tuberculosis. The fight against tuberculosis has been hampered by the burden of treatment regimens and drug resistance, and clinical trials are ongoing. A COS for tuberculosis will ensure that outcome selection across trials is consistent, free from selection bias and relevant to patients, clinicians and policy-makers. MEDLINE, EMBASE and ASSIA were searched for studies exploring patient perspectives on tuberculosis outcomes and their value. Each search strategy included terms for 1) qualitative research and 2) tuberculosis. Inclusion criteria: participants of any age with a diagnosis of tuberculosis; direct contact or observation; any geographical location; publication after 2003 and in English. Studies were appraised using the CASP checklist. Methods for synthesis should be based on the aims of review. Here, the aim is not model or theory generation, but an aggregation of perspectives and experiences. Thematic analysis was therefore used.