Key result
Repeat administration of an adenoviral vector to injured canine femoral arteries significantly enhanced lacZ expression at 1 week and reinduced it at 25% to 30% of full levels at 2-8 weeks.
Why the study?
Does repeat administration of a recombinant adenoviral vector enhance or reinduce transgene expression in balloon-injured canine femoral arteries?
Population
Dogs with balloon-injured femoral arteries
Comparison
Repeat administration of a recombinant… vs Single dose of adenoviral vector
Design
Preclinical
Follow-up
Up to 8 weeks
Authors
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May enable repeat adenoviral dosing in vascular gene therapy despite immunity; leaves open human translation from this canine model.
Does repeat administration of a recombinant adenoviral vector enhance or reinduce transgene expression in balloon-injured canine femoral arteries?
Repeat adenovirus-mediated gene transfer into injured arteries can enhance or partially reinduce gene expression despite the presence of an immune response.
Ueno et al. (1995) studied Balloon-injured femoral arteries. Repeat administration of recombinant adenoviral vector expressing E. coli lacZ vs. Single dose was evaluated on lacZ expression. Repeat administration of an adenoviral vector to injured canine femoral arteries significantly enhanced lacZ expression at 1 week and reinduced it at 25% to 30% of full levels at 2-8 weeks.
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