Key result
The addition of levocarnitine and arginine to standard rehabilitation shortened hemodynamic recovery time and lowered the total dose of inotropic drugs compared to control.
Why the study?
The study aimed to develop and implement comprehensive rehabilitation for cardiac surgery patients with acute left ventricular failure undergoing on-pump coronary artery bypass grafting.
Does metabolic support with levocarnitine and arginine improve hemodynamic recovery and reduce inotropic drug requirements in patients with acute left ventricular failure after on-pump CABG?
Does metabolic support with levocarnitine and arginine improve hemodynamic recovery and reduce inotropic drug requirements in patients with acute left ventricular failure after on-pump CABG?
Answers are grounded in this paper and cite their sources.
Adding levocarnitine and arginine to standard rehabilitation may accelerate hemodynamic recovery and reduce ICU stay in patients with acute heart failure following on-pump CABG.
Aim: To develop and implement a comprehensive rehabilitation of cardiosurgical patients with acute left ventricular failure who underwent on-pump coronary artery bypass grafting. Materials and Methods: 500 patients underwent on-pump coronary artery bypass grafting. Sixty patients who required inotropic support in the postoperative period were selected. The patients were divided into two groups of 30 people each. In both groups, psychological and physical rehabilitation was carried out in accordance with the algorithm developed by us. The protocol EACTS, 2017 for the main group was supplemented with a metabolic support component, the introduction of a combination of levocarnitine and arginine. Results: Psychological and physical algorithm was developed and implemented. In the basic group, the recovery time of hemodynamics and the total dose of the inotropic drug were shorter/lower than in the control one. Conclusions: Stressful moments informing the patient in the perioperative period is a powerful tool for psychological rehabilitation. Aerobic training and respiratory physiotherapy are mandatory elements of physical rehabilitation. The introduction of a combination of levocarnitine and arginine has a positive effect on the terms of activation of patients, and reduces the stay in the intensive care unit.
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Cherniy et al. (2022) studied Acute left ventricular failure post-coronary artery bypass grafting (n=60). Levocarnitine and arginine vs. Standard rehabilitation (EACTS 2017 protocol) was evaluated on Recovery time of hemodynamics and total dose of inotropic drug. The addition of levocarnitine and arginine to standard rehabilitation shortened hemodynamic recovery time and lowered the total dose of inotropic drugs compared to control.
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