More than a dozen examples verify that ethers are cleaved regioselectively in very good yields by MeSiCl3/NaI in acetonitrile; primary and secondary methyl‐, benzyl‐, trityl‐ and tetrahydropyranyl ethers directly afford the primary and secondary alcohols. In the case of tert‐alkylmethyl ethers only the tert‐alkyl iodides are formed. equation image
No takes yet. Share an insight, caveat, or question.
Olah et al. (1981) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: