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This study highlights the nephron-protective effects of Trigonella foenumgreacum (TFG) in combination with ginger, Zingiber officinale (GZO) in alloxaninduced diabetic rats. The alloxan-induced diabetic rat is a commonly used experimental animal model of diabetes and induces acute renal tubule interstitial nephritis, hence leading to nephrotoxicity. Forty rats were divided into four groups; normal control rats, diabetic control rats, diabetic rats treated TFG in combination with GZO, and diabetic rats treated with glibenclamide as a positive control. TFG in combination with GZO was administered orally for 6 weeks to alloxan-treated rats, and they were compared with the control and diabetic groups, respectively. The results of this study showed that diabetes mellitus induced by alloxan produced pronounced nephrotoxic effects, with a significant increase in the concentration of serum glucose and creatinine concentration, with a significant decrease in total proteins. Histopathologically, a fragmented and congested appearance of the glomerulus and degenerating and necrotic tubule epithelia were observed in the renal cortex. Administration of TFG in combination with GZO significantly decreased glucose and creatinine concentrations, while significantly increasing total protein concentrations in alloxan-induced diabetic rats. In addition, the medicinal plant treatment resulted in an improvement of histopathological changes.
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Alalwani AD (2019) studied this question.
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