Abstract magnified image Inexpensive copper catalysts allow for efficient syntheses of N‐aryl‐, N‐acyl‐, or N‐H‐(aza)indoles starting from ortho‐alkynylbromoarenes. The broad scope of this domino N‐arylation/hydroamin(d)ation process is highlighted by the synthesis of highly functionalized indoles, as well as of a Chek1/KDR inhibitor pharmacophore.
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Ackermann et al. (2009) studied this question.
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