Safety and superior immunogenicity of heterologous boosting with an RBD-based SARS-CoV-2 mRNA vaccine in Chinese adults

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  Fig. 1. Safety and immunogenicity of heterologous boosting with AWcorna in Chinese adults. a Geometric mean titer (GMT) of neutralizing antibodies to live WT SARS-CoV-2. The WHO reference serum (1000 IU/mL) was equivalent to a live viral neutralizing antibody titer of 1:139 against WT. b GMT of neutralizing antibodies to the Delta variant. The WHO reference was 1:213 against the Delta variant (the dash line in red). Eligible participants primed with 2 doses of inactivated vaccine were randomly allocated to AWcorna group (n = 200) and CoronaVac group (n = 100) to receive a booster dose. c GMT of neutralizing antibodies to the Omicron variant was measured in the subgroup (120 participants with the first 120 subject numbers, 80 from AWcorna and 40 from CoronaVac group). Sera were measured 28 days after booster only, and thus no baseline analysis was performed. d Seropositive rates (%) of neutralizing antibody to the Omicron variant. e GMTs of anti-RBD IgG antibodies to WT SARS-CoV-2. The WHO reference (1000 binding antibody unit (BAU)/mL in serum) is equivalent to an RBD-specific IgG ELISA antibody titer of 1:5490. The cutoff value for the response was 1:8 for live virus neutralizing…