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Human lymphocytes stimulated with phytohaemagglutinin in vitro show maximal 14C‐thymidine incorporation when the gas phase of the cultures contains 20% O2. The rate of DNA synthesis is more affected by hyperoxic conditions than by hypoxia. Cell viability, defined by dye exclusion, is considerably less dependent on pO2 than is cellular replication.
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Andersen et al. (1968) studied this question.
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