The Differential Toxicity of Ammonium Salts

Intravenous LD50's were determined in young Swiss albino mice, weighing 18 to 22 Gm. (average, 19.7 Gm.). One ml. of isotonic saline containing the ammonium compounds (reagent grade) in varying concentrations was injected into a tail vein during an average time of 1.9 seconds. The lethal effect was determined in 10 animals for each of three to five concentration levels. The mice were observed continually until all signs of acute toxicity disappeared and then were examined during the course of several days for the appearance of any latent toxicity. Blood pH was determined with a Beckman Model GS