Valuable tools for experimental anti-inflammatory therapy and for clarifying the biological role of neutral sphingomyelinase and ceramide might be represented by manumycins. The antibiotic manumycin A (1), known as a Ras farnesyltransferase inhibitor, and some of its analogues were identified as irreversible inhibitors of neutral sphingomyelinase. The simple analogue 2 is readily accessible, stable and hitherto represents the most potent irreversible inhibitor of neutral sphingomyelinase.
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Arenz et al. (2001) studied this question.
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