Influence of ranitidine on plasma metoprolol concentrations.

Hypocholesterolaemia and cancer? SIR,-The largest study so far was not mentioned in Dr K G Taylor's leading article (21 May, p 1598). In an international collaborative analysis,' which included a large UK centre, we found that the association with a low serum cholesterol concentration was not specific for colon cancer and that it was almost entirely short term. (table). It seems that the main, and Mean difference in cholesterol concentrations and number of deaths Mean cholesterol difference (mmol/l) Period of follow up (years) All cancers Colon cancer 1 -0-75 (70) -0-65 (4) 2-5 -0-10 (616) -0-23 (41) 6-10 -0-05 (798) +0-08 (60)