Multiple hepatocellular adenomas in a patient with a history of oral contraception

We report a previously undescribed association between multiple hepatocellular adenomas and the use of oral contraceptives in a 29-year-old woman. She underwent trisegmentectomy, with 90% of the liver resected. Based on the rather large size of some of the adenomas at the time of diagnosis, most likely, the lesions were already present years before they were discovered. The liver was fully regenerated 6 months after surgery. Four years later, multiple adenomas recurred. During work-up for a liver transplant, she was found to have cryptococcal meningitis and pneumohydrocephalus which caused her demise.