The present report comprises a series of human brain infections withStreptococcus pyogenes, together with the results of experimental inoculation of streptococci in the brains of guinea-pigs. The human cases have been studied histologically with particular reference to, first, the age of the exudations; secondly, certain prominent vascular lesions; thirdly, the neuroglia reaction. The guinea-pig tissues are of value mainly in the study of the exudation. The work has been carried on with methods like those employed in two previous studies, on infections withStaphylococcus pyogenes aureus1and with pneumococcus.2 We have little evidence to bring on the vexed question of the relationship of pneumococcus and streptococcus. The lesions reported here differ in no constant feature from those reported by Southard and Keene in 1905 for the pneumococcus.2The effects of the two organisms on tissues, so far as observable by the methods used, would place the
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E. E. Southard (1906) studied this question.