Key result
The NEWS2 score more accurately predicted 1-week mortality in patients with pulmonary embolism (AUC 0.870) compared to the NEWS (AUC 0.854) and qSOFA score (AUC 0.789).
Why the study?
To determine the predictive ability of the NEWS, NEWS2, and qSOFA scores for the prognosis of pulmonary embolism in the emergency department.
Do NEWS, NEWS2, and qSOFA scores predict 1-week mortality in patients with pulmonary embolism in the emergency department?
Observational (n=245)
No
Do NEWS, NEWS2, and qSOFA scores predict 1-week mortality in patients with pulmonary embolism in the emergency department?
Effect estimate: AUC 0.870 (95% CI 0.825-0.915)
Absolute Event Rate: 0.87% vs 0.854%
p-value: p=<0.001
NEWS2 more accurately predicts 1-week mortality than NEWS and qSOFA scores in patients presenting to the emergency department with pulmonary embolism.
NEWS2 may enhance short-term mortality prediction in ED PE; hypothesis-generating and requires prospective validation before practice change.
OBJECTIVE: To determine the prediction ability of the National Early Warning Score (NEWS), National Early Warning Score 2 (NEWS2), and quick Sequential Organ Failure Assessment (qSOFA) score for the prognosis of pulmonary embolism (PE) in the emergency department. METHODS: This retrospective study involved 245 patients with PE. The NEWS, NEWS2, and qSOFA scores were compared according to the hospitalization clinic (ward vs. intensive care unit), hospitalization length (<10 vs. >10 days), severity of embolism (massive vs. submassive), and outcome (discharged vs. died). RESULTS: The areas under the curve of the NEWS, NEWS2, and qSOFA score for 1-week mortality were 0.854 (sensitivity, 78%; specificity, 73%; cutoff, 7.5; confidence interval, 0.807-0.902), 0.870 (sensitivity, 83%; specificity, 73%; cutoff, 5.5; confidence interval, 0.825-0.915), and 0.789 (sensitivity, 83%; specificity, 51%; cutoff, 0.5; confidence interval, 0.720-0.858), respectively. CONCLUSION: The NEWS2 more accurately predicts 1-week mortality than do the NEWS and qSOFA score in patients with PE.
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Yolcu et al. (2022) conducted an observational in Pulmonary embolism (n=245). NEWS2 score vs. NEWS and qSOFA scores was evaluated on 1-week mortality prediction (Area Under the Curve) (AUC 0.870, 95% CI 0.825-0.915, p=<0.001). The NEWS2 score more accurately predicted 1-week mortality in patients with pulmonary embolism (AUC 0.870) compared to the NEWS (AUC 0.854) and qSOFA score (AUC 0.789).
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