LiClO4 Induced One Pot Three‐Component Aminoalkylation of Aldehydes LiClO4‐mediated one‐pot reaction of isobutyraldehyde (1) or benzaldehyde (5) with (trimethylsilyl)dialkylamines 2 and C nucleophiles such as O‐silylated ketene acetals 3, 6, allyl Grignard, lithium (trimethylsilyl)acetylide, triinethylsilyl cyanide, and diethylzinc afforded in high yields the corresponding aminoalkylation products 4 and 7–13. The lithium enolate of cyclohexanone adds in 5 M LiClO4 solution in an Ik manner to the corresponding mannich base (19, 20) with good yield.
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Saidi et al. (1994) studied this question.
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