A 5-year retrospective study comparing bone flap replacement with acrylic cranioplasty was carried out. There was no significant difference in the high infection rates associated with the two procedures. We suggest that antibiotic-impregnated acrylic cranioplasty may be the safest and best surgical procedure based on the orthopaedic experience with gentamicin-impregnated cement in joint replacement surgery.
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Aziz et al. (1990) studied this question.
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