Some Observations on Bleeding Tendency in Thrombocytopenic Purpura

Article1 September 1947SOME OBSERVATIONS ON BLEEDING TENDENCY IN THROMBOCYTOPENIC PURPURAJ. GARROTT ALLEN, GEORGE BOGARDUS, L. O. JACOBSON, CHARLES L. SPURRJ. GARROTT ALLENSearch for more papers by this author, GEORGE BOGARDUSSearch for more papers by this author, L. O. JACOBSONSearch for more papers by this author, CHARLES L. SPURRSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-3-382 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous communication it was reported that in irradiation hemorrhage (roentgen-ray) an anticoagulant was present in the blood.1This anticoagulant was indistinguishable from heparin. The hemorrhagic tendency in dogs could be prevented or stopped temporarily by the intravenous injection of protamine sulfate or toluidine blue. Both of these substances are capable of binding heparin and rendering it biologically inactive so far as its anticoagulant properties are concerned. They do not appear to affect any other phase of the clotting mechanism except to act as anticoagulants when present in excess.1These agents were effective even in the face of marked...Bibliography1. ALLENJACOBSON JGLO: Hyperheparinemia: Cause of the hemorrhagic syndrome associated with total body exposure to ionizing radiation, Science, 1947, cv, 2728. Google Scholar2. WINTROBE MN: Clinical hematology, 1946, Lea and Febiger, Philadelphia. Google Scholar3. TOCANTINS LM: The mammalian blood platelet in health and disease, Medicine, 1938, xvii, 155-260. CrossrefGoogle Scholar4. BRILLROSENTHAL : Quoted by Tocantins, ibid., 1938. Google Scholar5. BOGARDUSALLENJACOBSONSPURR GJGLOCL: The rôle of splenectomy in thrombocytopenic purpura. In press. Google Scholar6. Unpublished data, 1947. Google Scholar7. ELLIOTT RH: A reëvaluation of splenectomy in thrombocytopenic purpura based on a 27 year combined clinic follow up experience, Proc. Inst. Med. Chicago, 1947, xvi, 330. Google Scholar8. ALLENSANDERSONMILHAMKIRSCHONJACOBSON JGMMALO: Hyperheparinemia and the hemorrhagic syndrome following total body exposure to ionizing radiation. In press, 1947. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presented at the Twenty-Eighth Annual Session of the American College of Physicians, Chicago, May 1, 1947.From the Department of Surgery and Medicine of the University of Chicago.This work has been aided by a grant from the Douglas Smith Foundation for Medical Research of the University of Chicago. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by[6] Radioimmunoassay of platelet factor 4Proteins Secreted by Platelets: Significance in Detecting ThrombosisBIBLIOGRAPHYQuantitative und qualitative Befunde zur Beurteilung von Blutgerinnung und BlutstillungHeparin and Thrombocytopenia in Experimental Burn InjuriesInhibition of Thrombocytopenia and 5-Hydroxytryptamine Release in Anaphylactic Shock by HeparinThrombocytenfaktorenLabiler Hypertonus und Manifestationsrhythmus einer chronisch-thrombocytopenischen PurpuraGerinnungsphysiologische und Plasmaeiwei�untersuchungen bei normalen (Menses) und pathologischen uterinen BlutungenCongenital hemorrhagic diathesis of the prothrombin complexUntersuchungen �ber die H�mostase uteriner Blutungen durch Protaminsulfat und ToluidinblauToluidine blue—An evaluation in the treatment of uterine bleedingDifferential diagnosis, pathogenesis and treatment of the thrombocytopenic purpurasThe Role of Anticoagulant Therapy in SurgeryDie Therapie der hämorrhagischen DiathesenIdiopathic Thrombopenic Purpura in ChildhoodINVESTIGATIONS IN A CASE OF URTICARIA PIGMENTOSA.Congenital and Neonatal Thrombocytopenic PurpuraACTIVITY OF PLASMA LABILE FACTOR IN DISEASECongenital thrombocytopenic purpura of the newborn infantThe Use of Anticoagulants Following Transurethral Prostatic ResectionTHE RESPONSE OF ACUTE LEUKEMIA TO THE ADMINISTRATION OF THE FOLIC ACID ANTAGONISTS, AMINOPTERIN AND AMETHOPTERIN: REPORT OF 14 CASES*MILTON S. SACKS, M.D., F.A.C.P., GEORGE T. BRADFORD, M.D., EMANUEL B. SCHOENBACH, M.D.Thrombasthenia and Thrombocytopenic PurpuraHemorrhagic DiseasesProthrombin: A Critique of Methods for Its Determination and Their Clinical SignificanceProtamine for Intravenous Use in Man and in Animal ExperimentsThe Problem of Essential Thrombocytopenic Purpura 1 September 1947Volume 27, Issue 3Page: 382-395KeywordsAnticoagulantsHemorrhageHeparinIntravenous injectionsProtaminesSurgery Issue Published: 1 September 1947 PDF downloadLoading ...