Key result
Biodegradable polymer drug-eluting stents were associated with decreased all-cause mortality compared to durable polymer stents in patients undergoing rotational atherectomy (HR 0.414; 95% CI 0.174-0.988).
Why the study?
The study aimed to compare the clinical outcomes of biodegradable polymer versus durable polymer DES in patients with calcified coronary lesions who underwent rotational atherectomy and PCI.
Does biodegradable polymer DES reduce 3-year all-cause mortality compared to durable polymer DES in patients with calcified coronary lesions undergoing rotational atherectomy?
Cohort (n=540)
Yes
Does biodegradable polymer DES reduce 3-year all-cause mortality compared to durable polymer DES in patients with calcified coronary lesions undergoing rotational atherectomy?
In patients with calcified coronary lesions undergoing rotational atherectomy, the use of biodegradable polymer DES was associated with significantly lower all-cause mortality compared to durable polymer DES.
Supports BP-DES evaluation in atherectomy-treated calcified lesions; hypothesis-generating and should not yet change practice.
BACKGROUND: The aim of this study was to compare the clinical outcomes of biodegradable polymer (BP) versus durable polymer (DP) drug eluting stents (DES) in patients with calcified coronary lesions who underwent rotational atherectomy (RA) and percutaneous coronary intervention (PCI). METHODS: This study was based on a multicenter registry which enrolled patients with calcified coronary artery disease who received PCI using RA during between January 2010 and October 2019 from 9 tertiary centers in Korea. The primary outcome was 3-year all-cause mortality, and the secondary outcomes were cardiovascular death and target-lesion failure. RESULTS: A total of 540 patients who underwent PCI using RA were enrolled with a follow-up period of median 16.1 months. From this registry, 272 patients with PCI using DP-DES and 238 patients with BP-SGDES were selected for analysis. PCI with BP-DES was associated with decreased all-cause mortality after propensity score matching (HR 0.414, CI 0.174-0.988) and multivariate Cox regression analysis (HR 0.458, HR 0.224-0.940). BP-DES was also associated with decreased cardiovascular mortality, but there was no difference in TLF between the two groups. CONCLUSIONS: BP-DES were associated with favorable outcomes compared to DP-DES in patients undergoing PCI using RA for calcified coronary lesions.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2022) conducted a cohort in Calcified coronary artery disease (n=540). Biodegradable polymer drug eluting stents vs. Durable polymer drug eluting stents was evaluated on 3-year all-cause mortality (HR 0.414, 95% CI 0.174-0.988). Biodegradable polymer drug-eluting stents were associated with decreased all-cause mortality compared to durable polymer stents in patients undergoing rotational atherectomy (HR 0.414; 95% CI 0.174-0.988).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: