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We have shown, by means of the Frank and Goldberger test, that of our 186 schizophrenic subjects 129 (69.35 per cent) show a negative reaction, or no demonstrable quantity of blood estrin. 2. By the same test we have shown that of our 50 normal menstruating women only 4 (8 per cent) show no demonstrable estrin. 3. From this evidence we conclude that in schizophrenia (female subjects) there is a definite imbalance of the gonotropic and gonad stimulating hormones. 4. We suggest the use of theelin (replacement) therapy as a factor in treatment of certain cases of schizophrenia occurring in the female. 5. We realize the important part that the hypophyseal and corpus luteum hormones may play in this imbalance but leave concluding statements on this relation for future investigation.
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Sears et al. (1937) studied this question.
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