December 2, 2009Synlett
Asymmetric Brønsted Acid Catalyzed Nucleophilic Addition to in situ Generated Chiral N-Acyliminium Ions
Authors
Abstract
A new enantioselective Brønsted acid catalyzed nucleophilic substitution of γ-hydroxylactams with indole is presented. The reaction proceeds via an intermediary N-acyliminium ion and provides disubstituted γ-lactams in good yields and with high enantioselectivities.
Discussion
No takes yet. Share an insight, caveat, or question.
Cite This Study
Rueping et al. (2009) studied this question.