Observations on Patients with Laennec's Cirrhosis Receiving Alcohol While on Controlled Diets

Article1 May 1964Observations on Patients with Laennec's Cirrhosis Receiving Alcohol While on Controlled DietsESAT ERENOGLU, M.D., JUAN G. EDREIRA, M.D., ARTHUR J. PATEK JR., M.D.ESAT ERENOGLU, M.D., JUAN G. EDREIRA, M.D., ARTHUR J. PATEK JR., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-5-814 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe close relationship between chronic alcoholism and Laennec's cirrhosis has been known for many years, but the manner in which alcoholism predisposes to cirrhosis of the liver is not understood. On the basis of clinical observations (1-3) it has been suggested that malnutrition may play an important etiological role in "alcoholic" cirrhosis, since the patients generally are malnourished, and since hepatic functions improve when patients are fed a nutritious diet and are deprived of alcohol. There is evidence that the ingestion of alcohol increases nutritional imbalance by providing calories without essential nutrients. Such a mechanism has been postulated as the...References1. PATEK AJ: Treatment of alcoholic cirrhosis of the liver with high vitamin therapy. Proc. Soc. Exp. Biol. Med. 37: 329, 1937. CrossrefGoogle Scholar2. PATEKPOST AJJ: Treatment of cirrhosis of the liver by a nutritious diet and supplements rich in vitamin B complex. J. Clin. Invest. 20: 481, 1941. CrossrefMedlineGoogle Scholar3. PATEKPOSTRATNOFFMANKINHILLMAN AJJODHRW: Dietary treatment of cirrhosis of the liver. Results in 124 patients observed during a 10 year period. JAMA 138: 543, 1948. CrossrefMedlineGoogle Scholar4. SPIESDEWOLF TDHF: Observations on the etiological relationship of severe alcoholism in pellagra. Amer. J. Med. Sci. 186: 521, 1933. CrossrefGoogle Scholar5. STRAUSS MB: Etiology of "alcoholic" polyneuritis. Amer. J. Med. Sci. 189: 378, 1935. CrossrefGoogle Scholar6. 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PHILLIPSGABUZDADAVISON GBGJC: Comparative effects of a purified and an adequate diet on the course of fatty cirrhosis in the alcoholic. J. Clin. Invest. 31: 351, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Columbia University Research Service, Goldwater Memorial Hospital, and the Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York.This investigation was supported by grant A-2178 from the Institute of Arthritis and Metabolic Disorders, the Bourne Fund for the Study of Hepatic Disease, and the Health Research Council of the City of New York under contract U-1017.Requests for reprints should be addressed to Arthur J. Patek, Jr., M.D., Columbia University Research Service, Goldwater Memorial Hospital, Welfare Island, New York, New York. 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