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A parallel algorithm for finding a near-maximum independent set in a circle graph is presented. An independent set in a graph is a set of vertices, no two of which are adjacent. A maximum independent set is an independent set whose cardinality is the largest among all independent sets of a graph. The algorithm is modified for predicting the secondary structure in ribonucleic acids (RNA). The proposed system, composed of an n neural network array (where n is the number of edges in the circle graph of the number of possible base pairs), not only generates a near-maximum independent set but also predicts the secondary structure of ribonucleic acids within several hundred iteration steps. The simulator discovered several solutions which are more stable structures, in a sequence of 359 bases from the potato spindle tuber viroid, than previously proposed structures.
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Takefuji et al. (1990) studied this question.
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