Key result
This is a trial protocol evaluating whether ramipril 5 mg reduces cardiac fibrosis compared to placebo in patients with rheumatic mitral stenosis; no results are reported.
Why the study?
Chronic inflammation and fibrosis driven by angiotensin II cause mitral valve thickening in rheumatic heart disease, leading to the hypothesis that ACE inhibitors could improve rheumatic mitral valve stenosis.
Does ramipril reduce ST2 expression in mitral valve tissue in patients with rheumatic mitral valve stenosis undergoing valve replacement?
RCT
Double-blind
randomised
No
Does ramipril reduce ST2 expression in mitral valve tissue in patients with rheumatic mitral valve stenosis undergoing valve replacement?
The RamiRHeD trial protocol outlines a randomized study to assess whether preoperative ramipril can reduce valvular fibrosis, as measured by ST2 expression, in patients with rheumatic mitral stenosis.
No takes yet. Share an insight, caveat, or question.
Ramipril should not yet be used to reduce fibrosis in rheumatic mitral stenosis; this RCT protocol will test the hypothesis in a randomized setting.
Ambari et al. (2021) conducted an RCT in Rheumatic mitral stenosis. ramipril vs. placebo was evaluated on Expression of ST2 in the mitral valve and plasma ST2. This is a trial protocol evaluating whether ramipril 5 mg reduces cardiac fibrosis compared to placebo in patients with rheumatic mitral stenosis; no results are reported.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: